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In presence of rat cecal content in a concentration of 2% w/v, drug release rate increased to be within the official limits

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In selected cases with patent and closed FO respectively, a histological examination of the interatrial septum was undertaken

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In such cases, aerosolized pentamidine may be considered because of its lack of systemic absorption and the resultant lack of exposure of the developing embryo to the drug (CIII).